Detailed Product Description

Longacting filgrastim is a covalent conjugate of recombinant methionyl human GCSF (Filgrastim) and monomethoxypolyethylene glycol. Filgrastim is a watersoluble 175 amino acid protein with a molecular weight of approximately 19 kilodaltons (kD). Filgrastim is obtained from the bacterial fermentation of a strain of Escherichia. coli transformed with a genetically engineered plasmid containing the human G-CSF gene. To produce Pegfilgrastim, a 20 kD monomethoxypolyethylene glycol molecule is covalently bound to the Nterminal methionyl residue of Filgrastim. The average molecular weight of Pegfilgrastim is approximately 39 kD.